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Taking on DNA repair to tackle cancer

Pioneering therapeutics targeting the damage repair mechanism of DNA polymerase theta in a range of cancers have entered human trials – we tell the story from discovery to translation.

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Unravelling the mystery of Barrett’s oesophagus

Barrett’s oesophagus affects around 1 in every 100 to 200 people in the UK, and, for a small number of people, can develop into oesophageal cancer. But the origins of the condition have remained a mystery for decades, until now.

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How cancer hijacks cell death: a new view of metastasis

Professor Jody Rosenblatt tells us why dysregulated cell death could have an impact not only on metastasis, but also therapy resistance.

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Scientists find cells in centre of tumours are most likely to spread

The new findings shed light on how cancer cells found in different parts of a tumour behave differently.

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Stressed out – the cancer cells that survive chemotherapy, but at a cost

A group of Cancer Research UK-funded scientists are beginning to discover new vulnerabilities in cancer cells, which emerge when they enter ‘survival mode’.

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New method analyses DNA changes with ‘unprecedented accuracy’

Using the technology, scientists have revealed that cell division isn’t necessarily the main cause of genetic changes in human tissue DNA.

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Mutations in overlooked DNA could have profound impact on bowel cancer survival

DNA errors in the cell’s energy ‘factories’ increases the chances of survival for people with bowel cancer, according to a new study.

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Changes detected in BRCA1 breast cells before they turn cancerous

Scientists have mapped out some of the earliest changes that occur in seemingly healthy breast tissue long before any tumours appear.

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Antibiotic shows potential in helping treat aggressive blood cancer

New research shows a type of aggressive blood cancer could be made more sensitive to chemotherapy using an antibiotic currently available to treat diarrhoea.

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Gentle regular exercise could reduce the risk of liver cancer in mice

A team of Cancer Research UK-funded scientists have been investigating the role of exercise in reducing the risk of liver cancer in mice

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