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FOCUS4: Learning from a landmark clinical trial

FOCUS4 was a large-scale trial investigating new treatments in people with advanced or metastatic colorectal cancer. Running it may not have been without its challenges, but the learnings it provided us with are invaluable if we’re to run trials like it again. 

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Time to take on 9 new Cancer Grand Challenges

These are some of the biggest questions in cancer research. Cancer Grand Challenges are looking for research teams that can help answer them.

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Can cancer cells communicate?

Cancer cells use electricity to help them spread. A new study shows it might be key to controlling their other behaviours, too.

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The ecDNA story – catching the mastermind behind cancer evolution

Aggressive cancers use ecDNA to evolve quickly and resist treatment. This is how we found that out, and how we’re going to stop it.

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Stopping the spread: A revolution in how we think about metastasis

Research from our Cambridge Institute has shown us that metastasis isn’t a process unique to cancer, revolutionising the way we think about cell dissemination. 

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NICE doesn’t recommend olaparib for patients with certain prostate cancers

NICE does not recommend olaparib (Lynparza) for people with a type of advanced prostate cancer, as the treatment is not deemed cost-effective

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Inside Cancer Grand Challenges Part 1: what makes a grand challenge?

This entry is part 1 of 2 in the series Inside Cancer Grand Challenges

Today, Cancer Grand Challenges announced four new teams that have each received £20 million in funding to take on the biggest challenges in cancer research

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Picking out the patterns: How scientists are finding cancer’s signatures in tumour DNA

An international team of researchers have identified 21 common faults in cancer DNA using an algorithm that works similarly to Netflix

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Disease in a dish: Mini-gut organoids and the challenges of bowel cancer

Disrupted cell signalling, hijacked stem cells and the power of ‘mini-guts’ – we hear from Dr Vivian Li on the challenges and opportunities of developing colorectal cancer treatments.

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Taking on DNA repair to tackle cancer

Pioneering therapeutics targeting the damage repair mechanism of DNA polymerase theta in a range of cancers have entered human trials – we tell the story from discovery to translation.

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