Cancer biology

FOCUS4 was a large-scale trial investigating new treatments in people with advanced or metastatic colorectal cancer. Running it may not have been without its challenges, but the learnings it provided us with are invaluable if we’re to run trials like it again. 

These are some of the biggest questions in cancer research. Cancer Grand Challenges are looking for research teams that can help answer them.

Cancer cells use electricity to help them spread. A new study shows it might be key to controlling their other behaviours, too.

Aggressive cancers use ecDNA to evolve quickly and resist treatment. This is how we found that out, and how we’re going to stop it.

Research from our Cambridge Institute has shown us that metastasis isn’t a process unique to cancer, revolutionising the way we think about cell dissemination. 

NICE does not recommend olaparib (Lynparza) for people with a type of advanced prostate cancer, as the treatment is not deemed cost-effective

Today, Cancer Grand Challenges announced four new teams that have each received £20 million in funding to take on the biggest challenges in cancer research

An international team of researchers have identified 21 common faults in cancer DNA using an algorithm that works similarly to Netflix

Disrupted cell signalling, hijacked stem cells and the power of ‘mini-guts’ – we hear from Dr Vivian Li on the challenges and opportunities of developing colorectal cancer treatments.

Pioneering therapeutics targeting the damage repair mechanism of DNA polymerase theta in a range of cancers have entered human trials – we tell the story from discovery to translation.