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Why haven’t we cured cancer?

This entry is part 4 of 0 in the series Cancer Revolutionaries

Despite big improvements in survival, cancer is still one of the world’s biggest killers. Leading scientists explain why it presents such a challenge – and look at how far we’ve come

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Inside Cancer Grand Challenges Part 1: what makes a grand challenge?

This entry is part 1 of 0 in the series Inside Cancer Grand Challenges

Today, Cancer Grand Challenges announced four new teams that have each received £20 million in funding to take on the biggest challenges in cancer research

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Picking out the patterns: How scientists are finding cancer’s signatures in tumour DNA

An international team of researchers have identified 21 common faults in cancer DNA using an algorithm that works similarly to Netflix

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Stem cell research: meet the scientist growing ‘mini guts’ in her lab

This entry is part 1 of 0 in the series Cancer Revolutionaries

Vivian Li, group leader of the stem cell and cancer biology lab at the Francis Crick Institute, talks tumours and how she aims to target them.

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Disease in a dish: Mini-gut organoids and the challenges of bowel cancer

Disrupted cell signalling, hijacked stem cells and the power of ‘mini-guts’ – we hear from Dr Vivian Li on the challenges and opportunities of developing colorectal cancer treatments.

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Taking on DNA repair to tackle cancer

Pioneering therapeutics targeting the damage repair mechanism of DNA polymerase theta in a range of cancers have entered human trials – we tell the story from discovery to translation.

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Unravelling the mystery of Barrett’s oesophagus

Barrett’s oesophagus affects around 1 in every 100 to 200 people in the UK, and, for a small number of people, can develop into oesophageal cancer. But the origins of the condition have remained a mystery for decades, until now.

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How cancer hijacks cell death: a new view of metastasis

Professor Jody Rosenblatt tells us why dysregulated cell death could have an impact not only on metastasis, but also therapy resistance.

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Scientists find cells in centre of tumours are most likely to spread

The new findings shed light on how cancer cells found in different parts of a tumour behave differently.

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Stressed out – the cancer cells that survive chemotherapy, but at a cost

A group of Cancer Research UK-funded scientists are beginning to discover new vulnerabilities in cancer cells, which emerge when they enter ‘survival mode’.

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