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Scientists discover how to beat resistance to standard leukaemia drug

Cancer Research UK-funded scientists at The Institute of Cancer Research (ICR) have revealed a technique to kill chronic myeloid leukaemia (CML) cells that have stopped responding to a targeted drug, according to research published in Cancer Cell today.

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New cancer imaging technique uses vitamin C to detect more aggressive tumours

Cancer Research UK scientists have developed a new imaging technique that uses vitamin C to detect cancers likely to be more aggressive or resistant to treatment.

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Unstable chromosomes cause resistance to cancer drugs

Cancer Research UK scientists have made an important step towards developing personalised bowel cancer treatment by identifying which tumours are more likely to become drug resistant, according to research published in Cancer Research today.

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‘Patchwork’ of gene faults could help predict cervical cancer drug success

Cancer Research UK scientists have discovered that cervical cancer patients who have a mixture of different genetic faults in their tumour at the start of treatment may be more likely to relapse, according to a study published in the British Journal of Cancer today (Wednesday).

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Scientists unlock key to tamoxifen resistance

Cancer Research UK funded scientists have discovered why some breast cancers are resistant to the commonly used drug tamoxifen, their findings are published in Cancer Research.

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Yeast ‘DNA damage sensor’ provides chemotherapy resistance clue

Cancer Research UK scientists have been part of an international collaboration that has revealed the structure of a protein found in simple yeast cells and shown how it flags up damaged DNA for repair. The results of their study are published in Nature* today (Thursday). The finding may provide clues as to how some cancer cells become resistant to certain chemotherapy drugs.

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Discovery ‘significant step’ in understanding leukaemia drug resistance

Scientists have pinpointed an enzyme responsible for breaking down and inactivating a key childhood leukaemia drug, which could help to explain why around 20 per cent of patients do not respond to therapy. Their findings are published in the Journal of Clinical Investigation* today (Monday).

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Scientists shed new light on why pancreatic cancer drugs can fail

Cancer Research UK scientists led an international team of investigators who have discovered a new mechanism that may explain why pancreatic cancer patients are often resistant to a common chemotherapy treatment called gemcitabine, according to a study published in Science today.

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Cancer Research UK scientists discover pattern of genetic faults to predict cancer drug success

A pattern of genetic defects in tumours could indicate whether ovarian cancer patients will respond to common chemotherapy drugs before treatment starts, reveals a Cancer Research UK study published in the Proceedings of the National Academy of Sciences* today (Monday).

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Scientists crack the code to tamoxifen resistance

Scientists crack the code to tamoxifen resistance

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