BRCA gene mutations

• Personal Stories

“Do whatever you can, I need to live - I have my little girl”: Lina's story

Lina tells the story of how a newly available targeted drug helped slow down the growth of faulty BRCA-driven cancer in her body, giving her more time to spend with her loved ones. Lina tells the story of how a newly available targeted drug helped slow down the growth of faulty BRCA-driven cancer in her body, giving her more time to spend with her loved ones.

28 October 2024

• Personal Stories

“It must be more than just bad luck – it must be genetic”: Three women with BRCA gene mutations share their experiences

As we look back on 30 years since the discovery of BRCA1, here three women with faulty BRCA genes share their experiences of cancer.   As we look back on 30 years since the discovery of BRCA1, here three women with faulty BRCA genes share their experiences of cancer.  

9 October 2024

• Science & Technology
• Health & Medicine

Introducing DIY steps to genetic testing could catch more BRCA-linked cancer cases

Our researchers have published a paper showing that their alternative BRCA testing pathway, BRCA-DIRECT, could be a more convenient way to test for faulty BRCA genes in people with breast cancer Our researchers have published a paper showing that their alternative BRCA testing pathway, BRCA-DIRECT, could be a more convenient way to test for faulty BRCA genes in people with breast cancer

1 October 2024

• Health & Medicine

Olaparib approved for 800 prostate and breast cancer patients in England

Olaparib, a targeted cancer drug discovered and developed with our funding, has been approved for hundreds of patients with certain breast and prostate cancers in England.  Olaparib, a targeted cancer drug discovered and developed with our funding, has been approved for hundreds of patients with certain breast and prostate cancers in England. 

11 April 2023

• Personal Stories

How serendipity sent this oncologist in search of a cure for cancer

Dr Hugo De La Peña, the face of our latest TV advert, explains how a second chance at life led to a career dedicated to curing cancer.   Dr Hugo De La Peña, the face of our latest TV advert, explains how a second chance at life led to a career dedicated to curing cancer.  

12 August 2022

• Science & Technology
• Health & Medicine

Prising open the trap: Getting to grips with targeted cancer drug resistance

Cancer Research UK-funded scientists are using innovative techniques to understand how resistance to a targeted cancer drug is unfolding. Cancer Research UK-funded scientists are using innovative techniques to understand how resistance to a targeted cancer drug is unfolding.

10 January 2022

• Science & Technology

Professor Stephen West awarded Cancer Research UK’s lifetime achievement prize

Professor Stephen West of the Francis Crick Institute has been awarded the Cancer Research UK lifetime achievement award for his pioneering work in DNA repair. Professor Stephen West of the Francis Crick Institute has been awarded the Cancer Research UK lifetime achievement award for his pioneering work in DNA repair.

3 October 2018

• Science & Technology
• Health & Medicine

NICE publishes new guidance for women at high risk of breast cancer

Almost half a million healthy women at high risk of breast cancer can now be offered drugs that can cut their chances of developing the disease. Almost half a million healthy women at high risk of breast cancer can now be offered drugs that can cut their chances of developing the disease.

25 June 2013

• Health & Medicine

Hundreds more breast cancer patients should be tested for BRCA1 gene

Leading breast cancer experts are calling for women under 50 diagnosed with triple-negative breast cancer to be offered testing for faults in the BRCA1 gene. Leading breast cancer experts are calling for women under 50 diagnosed with triple-negative breast cancer to be offered testing for faults in the BRCA1 gene.

15 February 2012

Scientists discover first DNA region to alter breast cancer risk in women with BRCA1 faults

Cancer Research UK scientists have identified a DNA region which can increase or decrease the high breast cancer risk associated with the BRCA1 gene. Cancer Research UK scientists have identified a DNA region which can increase or decrease the high breast cancer risk associated with the BRCA1 gene.

19 September 2010