Clinical trials of new anti-cancer drugs could be performed more quickly, effectively and economically if the latest imaging tools were routinely employed, according to experts from Cancer Research UK.
According to a review written by a Cancer Research UK advisory committee, to be published tomorrow (Wednesday) in the Journal of the National Cancer Institute*, too many study proposals do not take full advantage of technologies such as MRS (magnetic resonance spectroscopy) and PET (positron emission tomography). Without these tools, researchers could miss out on vital information about the effects of the drugs being tested.
The authors want to see more funding for the development of ways to make the most of these imaging tools, and to help routinely incorporate them in the design of early clinical trials in order to improve the speed and quality of drug development.
Lead author of the review and chair of Cancer Research UK’s PTAC** committee, Professor Paul Workman, based at the Cancer Research UK Centre for Cancer Therapeutics at The Institute of Cancer Research, said: “A fundamental part of clinical trials is that they should measure how drugs move through the body and what effects they have. Advances in technologies such as MRS and PET can improve how we monitor drugs, and can also reduce the need for invasive procedures such as biopsies.
“MRS and PET are increasingly available to researchers, allowing us to see inside cancer cells in the body. We need to ensure that we all make the best use of these technologies, which can often provide more detailed information than the alternatives.”
PET and MRS have the advantage that they reduce the need for taking blood samples and tissue biopsies, although invasive techniques will always remain a crucial part of the monitoring process.
Harpal Kumar, chief operating officer of Cancer Research UK, said: “Cancer Research UK already invests significantly in imaging technology and we plan to invest more in both equipment and specialists over the next few years to provide our institutes and clinical centres with the resources they need to accelerate drug development.
“This is just one aspect of how we plan to keep the UK at the forefront of cancer drug development.”
For media enquiries please contact Michael Regnier in the Cancer Research UK press office on 020 7061 8309 or, out of hours, the duty press officer on 07050 264059.
* JNCI, Vol. 98, No. 9, May 3, 2006
** PTAC – Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee
The term pharmacodynamic refers to what a drug does to the body, and pharmacokinetic to what the body does to the drug.
About Cancer Research UK
- Together with its partners and supporters, Cancer Research UK’s vision is to beat cancer.
- Cancer Research UK carries out world-class research to improve understanding of the disease and find out how to prevent, diagnose and treat different kinds of cancer.
- Cancer Research UK ensures that its findings are used to improve the lives of all cancer patients.
- Cancer Research UK helps people to understand cancer, the progress that is being made and the choices each person can make.
- Cancer Research UK works in partnership with others to achieve the greatest impact in the global fight against cancer.
For further information about Cancer Research UK’s work or to find out how to support the charity, please call 020 7009 8820 or visit the Cancer Research UK welcome page.
The Institute of Cancer Research
The Institute of Cancer Research is Europe’s leading cancer research centre with expert scientists working on cutting edge research. It was founded in 1909 to carry out research into the causes of cancer and to develop new strategies for its prevention, diagnosis, treatment and care. The Institute works in a unique partnership with The Royal Marsden NHS Foundation Trust, forming the largest comprehensive cancer centre in Europe. This relationship enables close daily contact with those on the frontline in the fight against cancer – the clinicians, the carers and most importantly, the patients.