A chemical commonly called baking soda which is found naturally in the body could be used to detect cancer with magnetic resonance imaging, reveals a Cancer Research UK study published in Nature* today (Wednesday).
Traditionally magnetic resonance imaging – or MRI – detects water and fat in the human body. By boosting MRI sensitivity more than 20,000 times – using a scanning technique developed by GE Healthcare – researchers can now image the molecules that cancer cells use to make energy and to grow.
This level of precision could be used to detect tumours and to find out if cancer treatments are working effectively at an earlier stage.
Almost all cancers have a lower pH than the surrounding tissue. Normally, the human body has a system of balancing chemicals with a low pH, acids, and chemicals with a high pH, alkalis, to maintain a constant, healthy pH level. In cancer, this balancing system is disturbed, and the tissue becomes more acidic.
Currently, there is no way to safely measure differences in pH in patients, but spotting these areas of acidity could be used to find cancers when they are very small.
Working with mice, the team found a new way to measure pH levels using this very sensitive MRI technique with a tagged form of bicarbonate. Bicarbonate, or baking soda, occurs naturally in the body, where it is involved in the acid-alkali balancing system.
Lead researcher Professor Kevin Brindle, from Cancer Research UK’s Cambridge Research Institute at the University of Cambridge, said: “This technique could be used as a highly-sensitive early warning system for the signs of cancer. Establishing such tools is a major challenge in cancer research.
“By exploiting the body’s natural pH balancing system, we have found a potentially safe way of measuring pH to see what’s going on inside patients. MRI can pick up on the abnormal pH levels found in cancer and it is possible that this could be used to pinpoint where the disease is present and when it is responding to treatment.”
Using MRI, they looked to see how much of the tagged bicarbonate was converted into carbon dioxide within the tumour. In more acidic tumours, more bicarbonate is converted into carbon dioxide.
First author of the study, Dr Ferdia Gallagher who is a Cancer Research UK and Royal College of Radiologists clinical training fellow, based at the University of Cambridge, said: “Although it’s early days, if this technique proves to be safe and effective in cancer patients it has the potential to be a crucial tool in detecting cancer earlier – which is often the key to successful treatment.”
Dr Gallagher, who is also a radiologist at Addenbrooke’s Hospital in Cambridge, added: “Our technique allows the spatial distribution of pH to be imaged using MRI which is something that has not previously been possible in patients. This new method is important because the chemical we use isn’t toxic and is already administered safely to humans.”
Dr Lesley Walker, director of cancer information at Cancer Research UK, said: “It’s really important that we find new ways of diagnosing cancer earlier and find out if drugs are working well in the body.
“So if clinical trials show that this technique is as safe and effective in cancer patients as we expect, this could be a very useful tool in the early detection of cancer and may save many lives.”
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* Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Gallagher et al. 2008. Nature.
About Magnetic Resonance Imaging (MRI)
MRI uses magnetism rather than X-rays (as in the case of computed tomography or CT) to produce a picture of the inside of the body. In an MRI scanner, the body is exposed to a magnetic field about 20,000 times stronger than the earth’s. This causes the atoms that make up the body to vibrate slightly, although the procedure is completely painless. These vibrations can be stimulated to release radio waves that are picked up by the scanner.
MRI scans can be used to view ‘slices’ through the body, or can make 3D images of organs. MRI allows soft tissues to be seen more easily than on CT and is therefore frequently used in imaging the brain, the heart, joints and tumours.
Cancer Research UK’s Clinical Research Training Fellowship Scheme
Dr Ferdia Gallagher is a Cancer Research UK and Royal College of Radiologists clinical training fellow. Cancer Research UK’s Clinical Research Training Fellowship Scheme is intended to support clinicians who wish to undertake a period of full-time training in a cancer relevant research field. In 2007, Cancer Research UK awarded seven Clinical Research Training Fellowship awards.
About the Cambridge Research Institute
The Cancer Research UK Cambridge Research Institute is a major new research centre which aims to take the scientific strengths of Cambridge to practical application for the benefit of cancer patients. The Institute is a unique partnership between the University of Cambridge and Cancer Research UK. It is housed in the Li Ka Shing Centre, a state-of-the-art research facility located on the Cambridge Biomedical Campus which was generously funded by Hutchison Whampoa Ltd, Cambridge University, Cancer Research UK, The Atlantic Philanthropies and a range of other donors.
About GE Healthcare
GE Healthcare provides transformational medical technologies and services that are shaping a new age of patient care. Our expertise in medical imaging and information technologies, medical diagnostics, patient monitoring systems, performance improvement, drug discovery, and biopharmaceutical manufacturing technologies is helping clinicians around the world re-imagine new ways to predict, diagnose, inform, treat and monitor disease, so patients can live their lives to the fullest.
GE Healthcare’s broad range of products and services enable healthcare providers to better diagnose and treat cancer, heart disease, neurological diseases and other conditions earlier. Our vision for the future is to enable a new “early health” model of care focused on earlier diagnosis, pre-symptomatic disease detection and disease prevention. Headquartered in the United Kingdom, GE Healthcare is a $17 billion unit of General Electric Company (NYSE: GE). Worldwide, GE Healthcare employs more than 46,000 people committed to serving healthcare professionals and their patients in more than 100 countries. For more information about GE Healthcare, visit the GE Healthcare website.
About Cancer Research UK
- Together with its partners and supporters, Cancer Research UK’s vision is to beat cancer.
- Cancer Research UK carries out world-class research to improve understanding of the disease and find out how to prevent, diagnose and treat different kinds of cancer.
- Cancer Research UK ensures that its findings are used to improve the lives of all cancer patients.
- Cancer Research UK helps people to understand cancer, the progress that is being made and the choices each person can make.
- Cancer Research UK works in partnership with others to achieve the greatest impact in the global fight against cancer.
- For further information about Cancer Research UK’s work or to find out how to support the charity, please call 020 7009 8820 or visit our homepage.
