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  • Health & Medicine

Can nicotine gum cause mouth cancer?

by Ed Yong | Analysis

24 April 2009

5 comments 5 comments

Gum.

February 2021 update. This blog post is based on a single study published in 2009, which caused alarming headlines. 

However, the best evidence available shows that nicotine does not cause mouth cancer, or any type of cancer. People have used nicotine replacement therapy safely for many years. 

Thinking about stopping smoking? Read more about the most effective ways to stop for good on our website. 

For people who want to stop smoking, there are many different options available. These include products based on nicotine, the addictive drug that keeps smokers hooked.

These “nicotine replacement therapies” or NRT can take the form of gum, patches, nasal sprays or tablets. In each case, they aim to help smokers wean themselves off tobacco by providing a hit of nicotine without any of the other cancer-causing substances found in cigarette smoke. NRT products work by giving less nicotine more slowly and are much less addictive.

This week, alarming headlines hit the newspapers claiming that the nicotine in these products could actually cause mouth cancer. But while the results are interesting, this conclusion and many of the news stories based on it are premature.

The study was published in the journal PLoS ONE. It looked at one specific gene – FOXM1 – and the protein that it encodes. FOXM1 is a “transcription factor”, a master protein that can switch other genes on or off. It’s often overactive in various cancers.

The researchers looked at samples of mouth cells grown in the lab and taken from 75 people, of whom 15 had mouth cancer. They found that high levels of FOXM1 activity were associated with mouth cancer. Compared to normal mouth cells, the gene was more active in those that were on the verge of becoming cancerous, and even more active in those that had actually turned into cancer cells.

The researchers then exposed the lab-grown mouth cells to concentrations of nicotine, similar to those that build up in the mouths of people who chew nicotine gum. They found that at these concentrations, nicotine switched on the FOXM1 gene in their cells, and speeded up the transformation of normal cells into cancerous ones.

That’s a surprise – there are around 70 cancer-causing substances (carcinogens) in tobacco products, but most scientists feel that nicotine isn’t one of them. It’s obviously very addictive and at high doses, it can be very poisonous, but it’s not regarded as a cause cancer.

Some studies have suggested that it could influence the growth of cancerous cells, but even that is controversial. Whatever the situation, it’s clear that the nicotine itself is either harmless or substantially less harmful than the full gamut of chemicals in tobacco smoke.

The researcher themselves say: “We’ve showed the FOXM1 gene is activated by nicotine in human mouth cells which raises the possibility that nicotine could potentially increase the risk of mouth cancer. We want to stress, however, that further research is needed to conclusively determine whether this is indeed the case. There is no doubt however about the harmful effects of smoking, so smokers should make every effort to quit.”

Caution needed

The research team are right to advise caution. While their results are interesting and based on sound science, we have to remember that the study was done in a relatively small number of cell samples that had been grown in the lab.

Experiments like this can raise questions that prompt further research but alone, they can’t be treated as convincing evidence that something causes cancer. Often, laboratory studies have reported that a certain chemical increases or reduces the risk of cancer, only for larger studies in actual people to contradict those results (take the case of vitamin supplements, as an example).

This view was echoed by Professor Robert West, Director of Tobacco Studies at Cancer Research UK’s Health Behaviour Research Centre, who has done a lot of work looking into NRT. He said:

“The interpretation is highly speculative and contradicted by evidence that many millions of people have been using nicotine replacement therapy with no increased risk of oral or any other cancer. If reports like this stop people using what for many would be a life-saving medication it would be very unfortunate.”

Professor West is certainly right that nicotine replacement therapy can save lives. Smoking is the single biggest cause of cancer in the UK, and indeed, it’s the main cause of mouth cancer.

Because of cancer, heart disease, stroke and other conditions, the average smoker loses 10 years of their life. Helping more people to become non-smokers is the single best thing we can do to reduce the number of people who develop cancer. And as a way of helping people to quit smoking, nicotine replacement therapy works.

In 2007, the Cochrane Collaboration reviewed 132 trials using NRT. It concluded that “all of the commercially available forms of NRT (gum, transdermal patch, nasal spray, inhaler and sublingual tablets/lozenges) can help people who make a quit attempt to increase their chances of successfully stopping smoking.” The best of these products managed to double the chances of quitting successfully. They even work if smokers receive no extra support from other sources.

For a smoker, the health hazards of continuing to smoke greatly outweigh any potential risks of using NRT – and of course, the latter can help you to quit. Dr Muy-Tech Teh, who led the new research, agrees. “Smoking is of course far more dangerous, and people who are using nicotine replacement to give up should continue to use it and consult their GPs if they are concerned. The important message is not to overuse it, and to follow advice on the packet.”

Ed

Reference

Gemenetzidis, E et al. (2009). FOXM1 Upregulation Is an Early Event in Human Squamous Cell Carcinoma and it Is Enhanced by Nicotine during Malignant Transformation. PLoS ONE. DOI: 10.1371/journal.pone.0004849


    Comments

  • Brianna
    31 December 2011

    To Bhawna: It says right on the back of the box to consult a doctor before using if you have High Blood Pressure and Diabetes. So I would not take it until you consult your Physician. Also, I do not believe this whole Nicotine Gum gives you mouth cancer thing that’s spreading around. I have been using this for awhile now and I do not have mouth cancer. And if it did, There is a small percentage of people who developed cancer from this product. If it was a huge percentage it wouldn’t be on the shelves. Plus everything causes cancer in some way. So would you rather get lung cancer or quit and risk the fact that you have a small percentage of a chance of getting mouth cancer compared to the high percentage change of getting lung cancer. I’d take that small risk. I’m not going to worry about it to much.

  • bhawna
    29 December 2011

    can diabetic n high blood pressure patients consume these chewing gums for quitting smoking???

  • Trudi
    11 May 2009

    I’m worried sick. I’ve been addicted to nico gum for ages!

  • Sue Clark
    25 April 2009

    Dear Prof West,

    Looking at your profile, I cannot help wondering if your ‘keen’ support for the use of nicotine replacement therapies have anything to do with your numerous grant funding bodies from ‘Pfizer’ and ‘GlaxoSmithKline’ who make these NRT products?

    I can see a SERIOUS conflict of interest here!

    BW,
    Sue

  • Dezmond Boroski
    24 April 2009

    Dear Prof Robert West,
    There are a number of evidence linking nicotine and cancer prior to the PloS ONE article. For example:
    A paper in Nature Medicine reports that nicotine induces angiogenesis and promoted tumour growth.
    http://www.nature.com/nm/journal/v7/n7/full/nm0701_833.html
    http://news.bbc.co.uk/1/hi/world/americas/1415031.stm

    Cochrane Review: NRT is not effective for tobacco chewers
    http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD004306/frame.html

    Lancet: Placebo 10% vs NRT 18% quit rate
    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-4SRFCCJ-13&_user=125872&_coverDate=06/20/2008&_rdoc=1&_fmt=full&_orig=search&_cdi=4886&_sort=d&_docanchor=&view=c&_acct=C000010240&_version=1&_urlVersion=0&_userid=125872&md5=9ec4d9853355a2fe6d5c662b47744ec1#secx9

    What do you say?

    Regards,
    Dez

    Comments

  • Brianna
    31 December 2011

    To Bhawna: It says right on the back of the box to consult a doctor before using if you have High Blood Pressure and Diabetes. So I would not take it until you consult your Physician. Also, I do not believe this whole Nicotine Gum gives you mouth cancer thing that’s spreading around. I have been using this for awhile now and I do not have mouth cancer. And if it did, There is a small percentage of people who developed cancer from this product. If it was a huge percentage it wouldn’t be on the shelves. Plus everything causes cancer in some way. So would you rather get lung cancer or quit and risk the fact that you have a small percentage of a chance of getting mouth cancer compared to the high percentage change of getting lung cancer. I’d take that small risk. I’m not going to worry about it to much.

  • bhawna
    29 December 2011

    can diabetic n high blood pressure patients consume these chewing gums for quitting smoking???

  • Trudi
    11 May 2009

    I’m worried sick. I’ve been addicted to nico gum for ages!

  • Sue Clark
    25 April 2009

    Dear Prof West,

    Looking at your profile, I cannot help wondering if your ‘keen’ support for the use of nicotine replacement therapies have anything to do with your numerous grant funding bodies from ‘Pfizer’ and ‘GlaxoSmithKline’ who make these NRT products?

    I can see a SERIOUS conflict of interest here!

    BW,
    Sue

  • Dezmond Boroski
    24 April 2009

    Dear Prof Robert West,
    There are a number of evidence linking nicotine and cancer prior to the PloS ONE article. For example:
    A paper in Nature Medicine reports that nicotine induces angiogenesis and promoted tumour growth.
    http://www.nature.com/nm/journal/v7/n7/full/nm0701_833.html
    http://news.bbc.co.uk/1/hi/world/americas/1415031.stm

    Cochrane Review: NRT is not effective for tobacco chewers
    http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD004306/frame.html

    Lancet: Placebo 10% vs NRT 18% quit rate
    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-4SRFCCJ-13&_user=125872&_coverDate=06/20/2008&_rdoc=1&_fmt=full&_orig=search&_cdi=4886&_sort=d&_docanchor=&view=c&_acct=C000010240&_version=1&_urlVersion=0&_userid=125872&md5=9ec4d9853355a2fe6d5c662b47744ec1#secx9

    What do you say?

    Regards,
    Dez