Cancer Research UK scientists have found that non-dividing cells are able to kick-start some cancers, challenging a long held belief that only dividing cells, like stem cells, cause the disease, according to research published online in PNAS today (Monday).
Looking at skin cells the researchers demonstrated that damaged, non-dividing cells were able to send signals to neighbouring cells telling them to divide and form the beginnings of a tumour.
Cancers are characterised by faulty cells dividing uncontrollably – rapidly building a mass of cells. Because of this it is generally assumed cancers only arise from dividing cells, such as stem cells, with genetic faults called mutations.
Instead, non-dividing cells are able to contribute to the beginnings of tumour formation through the inflammatory response – chemicals sent out by cells in response to damage.
In response to damage, the non-dividing cells that switch on a gene called MEK1 recruit adjacent cells that are able to divide to help form the bulk of the tumour.
But this alone is not enough to initiate a tumour. The damage also releases a molecule from skin cells called IL1 that helps speed up tumour development by stimulating cells to divide and helping tumours to form their own blood supply.
This molecule in turn attracts inflammatory cells, including macrophages, which contribute to tumour formation. They encourage the tumour’s blood supply to grow and suppress the tumour-fighting responses of the immune system.
Individually these steps do not start tumours but the researchers have shown that collectively, in response to damage, they can lead to cancer.
Professor Fiona Watt, lead researcher and deputy director of Cancer Research UK’s Cambridge Research Institute, said: “Since a hallmark of cancer is uncontrolled cell growth, it is widely assumed that tumours only arise from dividing cells. In contrast, our studies show that cells that do not divide can still contribute to tumour formation. These results suggest new therapeutic approaches to treating certain cancers.”
Dr Lesley Walker, director of cancer information at Cancer Research UK, said: “These intriguing results could really change our understanding of how cancers develop. The more we understand about the development of cancers, the more opportunities we have to design new treatments to block and prevent cancers progressing further.”
For media enquiries please contact the Cancer Research UK press office on 020 3469 8300 or, out of hours, the duty press officer on 07050 264 059.
Watt, F.M., et al Tumour formation initiated by nondividing epidermal cells via an inflammatory infiltrate (2010) Proceedings of the National Academy Sciences
About the Cambridge Research Institute
The Cancer Research UK Cambridge Research Institute is a major new research centre which aims to take the scientific strengths of Cambridge to practical application for the benefit of cancer patients.
The Institute is a unique partnership between the University of Cambridge and Cancer Research UK. It is housed in the Li Ka Shing Centre, a state-of-the-art research facility located on the Cambridge Biomedical Campus which was generously funded by Hutchison Whampoa Ltd, Cambridge University, Cancer Research UK, The Atlantic Philanthropies and a range of other donors.
For more information visit www.cambridgecancer.org.uk