Work starts on a cancer vaccine for people with Lynch syndrome

I have recently had endometrial cancer age 55. I have no family history of LS but have a MMR 2 and 6 loss. Some past patient data shows that some with a loss in both have not had LS but the BAGP says otherwise. The good work that is being done gives us and the next generation a glimmer of hope. Thank you.

Need updates on this

Great news about the upcoming work to create a vaccine for Lynch Syndrome but how do we stay abreast of the progress?

Great step waiting for this vaccine with 1000 eyes

I have Lynch which was picked up following endometrial cancer. Thank goodness my daughter does not have the gene . Good luck to the team in your efforts to find a vaccine for future generations.

I was adopted aged 10 weeks old, and have never met my birth parents, nor attempted to trace them or any siblings if there are any.
I have recently had a left hemicolectomy , splenectomy and distal pancreatectomy ( aged 71).
I like many Lynch sufferers have a defective MLH1 unmethylated gene, and have been informed I may have LS.
I am awaiting further genetic studies, whilst undergoing adjuvant chemotherapy!!. A vaccine for LS would be a great step forward.

I really hope they do find a vaccine as living with Lynch is difficult as is knowing my child may have it. The worry and anxiety can be hard to live with. The colonoscopies aren’t nice and are frequent. I had colon cancer age 34. Skin cancer age 44 and have just had a full hysterectomy including ovaries which has thrown me into full on menopause. My dad had bowel cancer aged 37 and had a number of operations and unfortunately succumb to prostate cancer age 69.
I think Lynch is more common than they think as many people do not know they have it.
I pray they do find something to help dramatically reduce the risk. Aspirin does seem to be beneficial, I was part of the clinical trial but is gave me gastrointestinal problems.

This work is so important
The difficulty is some Trusts don’t do what is expected under NICE guidence due to lack of funding.
To be referred for genetic testing is almost impossible.

I am 78 years old and have been diagnosed with lynch syndrome. My two daughters also have this faulty gene and are tested regularly. To date I have not developed any cancer but wholeheartedly welcome this lynchvax research and hope it is successful.

My husband was successfully treated with immunotherapy following his bowel cancer diagnosis. My daughter was found to have the faulty genes therefore she is being advised to consider having a hysterectomy at 40 years old, which is only 2 years away. A vaccine would be a game changer for our family, as it is likely one of her children will also be carrying the Lynch Syndrome gene.

Having had duodenum cancer followed by Lynch diagnosis. Also having a strong history of bowel cancer within the wider family as a result of lynch. While understandably the main preventative diagnostics focus is on bowel cancer, Lynchies do get other rare cancers and knowledge is key. A vaccine sounds a really positive way forward, if not for me my daughter should she carry the gene when tested in a few years time!

I had a full hysterectomy (age 62), because of endometrial cancer. It was found I had a faulty gene and was put forward for Lynch genetic testing. It took a long time to get a final decision but luckily it was decided I didn’t have Lynch syndrome. After going through all this, having a possible vaccination for people with Lynch can’t be anything other than good.

It’s fantastic that they’re working on a vaccine for Lynch Syndrome and I wish the team the very best of luck! It may take years before the vaccine is created, but suffering will be reduced and lives saved if it works. The research might even help prevent other cancers too.

I hope that a vaccine can be achieved to help people with Lynch , if not for myself but my daughters & possible future family generations diagnosed with it .

I am hopeful that it will be done.

Very interesting to read of the article
about Lynch Syndrome and the work being carried out on a vaccine. Hope it will be successful.