Drug resistance

• Science & Technology

Unstable chromosomes cause resistance to cancer drugs

Cancer Research UK scientists have made an important step towards developing personalised bowel cancer treatment by identifying which tumours are more likely to become drug resistant, according to research published in Cancer Research today. Cancer Research UK scientists have made an important step towards developing personalised bowel cancer treatment by identifying which tumours are more likely to become drug resistant, according to research published in Cancer Research today.

1 March 2011

• Science & Technology

'Patchwork' of gene faults could help predict cervical cancer drug success

Cancer Research UK scientists have discovered that cervical cancer patients who have a mixture of different genetic faults in their tumour at the start of treatment may be more likely to relapse, according to a study published in the British Journal of Cancer today (Wednesday). Cancer Research UK scientists have discovered that cervical cancer patients who have a mixture of different genetic faults in their tumour at the start of treatment may be more likely to relapse, according to a study published in the British Journal of Cancer today (Wednesday).

19 January 2011

• Science & Technology
• Health & Medicine

Scientists unlock key to tamoxifen resistance

Cancer Research UK funded scientists have discovered why some breast cancers are resistant to the commonly used drug tamoxifen, their findings are published in Cancer Research. Cancer Research UK funded scientists have discovered why some breast cancers are resistant to the commonly used drug tamoxifen, their findings are published in Cancer Research.

23 February 2010

• Health & Medicine

Yeast 'DNA damage sensor' provides chemotherapy resistance clue

Cancer Research UK scientists have been part of an international collaboration that has revealed the structure of a protein found in simple yeast cells and shown how it flags up damaged DNA for repair. The results of their study are published in Nature* today (Thursday). The finding may provide clues as to how some cancer cells become resistant to certain chemotherapy drugs. Cancer Research UK scientists have been part of an international collaboration that has revealed the structure of a protein found in simple yeast cells and shown how it flags up damaged DNA for repair. The results of their study are published in Nature* today (Thursday). The finding may provide clues as to how some cancer cells become resistant to certain chemotherapy drugs.

11 June 2009

• Health & Medicine

Discovery 'significant step' in understanding leukaemia drug resistance

Scientists have pinpointed an enzyme responsible for breaking down and inactivating a key childhood leukaemia drug, which could help to explain why around 20 per cent of patients do not respond to therapy. Their findings are published in the Journal of Clinical Investigation* today (Monday). Scientists have pinpointed an enzyme responsible for breaking down and inactivating a key childhood leukaemia drug, which could help to explain why around 20 per cent of patients do not respond to therapy. Their findings are published in the Journal of Clinical Investigation* today (Monday).

8 June 2009

• Health & Medicine

Scientists shed new light on why pancreatic cancer drugs can fail

Cancer Research UK scientists led an international team of investigators who have discovered a new mechanism that may explain why pancreatic cancer patients are often resistant to a common chemotherapy treatment called gemcitabine, according to a study published in Science today. Cancer Research UK scientists led an international team of investigators who have discovered a new mechanism that may explain why pancreatic cancer patients are often resistant to a common chemotherapy treatment called gemcitabine, according to a study published in Science today.

21 May 2009

• Health & Medicine

Cancer Research UK scientists discover pattern of genetic faults to predict cancer drug success

A pattern of genetic defects in tumours could indicate whether ovarian cancer patients will respond to common chemotherapy drugs before treatment starts, reveals a Cancer Research UK study published in the Proceedings of the National Academy of Sciences* today (Monday). A pattern of genetic defects in tumours could indicate whether ovarian cancer patients will respond to common chemotherapy drugs before treatment starts, reveals a Cancer Research UK study published in the Proceedings of the National Academy of Sciences* today (Monday).

4 May 2009

• Health & Medicine

Scientists crack the code to tamoxifen resistance

Scientists crack the code to tamoxifen resistance Scientists crack the code to tamoxifen resistance

12 November 2008

Cancer Research UK invests Ј10m in drug discovery

Cancer Research UK is investing Ј10m in drug discovery projects at four universities across the UK. Cancer Research UK is investing Ј10m in drug discovery projects at four universities across the UK.

15 January 2008

Scientists develop new drug to outflank cancer resistance

A new drug has shown promising results against breast and prostate cancer cells and tumours that are resistant to conventional hormone-based treatments, according to research published in the British Journal of Cancer. A new drug has shown promising results against breast and prostate cancer cells and tumours that are resistant to conventional hormone-based treatments, according to research published in the British Journal of Cancer.

11 December 2007

Chromosomal instability may predict resistance to cancer drug

Chromosomal instability may be linked to the resistance that some cancers have to certain anticancer therapies, according to research published in Cancer Cell. Identifying tumours without chromosomal instability might, therefore, help to target these therapies selectively to patients more likely to benefit. Chromosomal instability may be linked to the resistance that some cancers have to certain anticancer therapies, according to research published in Cancer Cell. Identifying tumours without chromosomal instability might, therefore, help to target these therapies selectively to patients more likely to benefit.

11 June 2007

New hope for ways to overcome drug resistance in lung cancer

New hope for ways to overcome drug resistance in lung cancer New hope for ways to overcome drug resistance in lung cancer

12 July 2006