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Bowelbabe Fund celebrates raising £20m by announcing the Bowelbabe Vaccine

Sophie Wedekind
by Sophie Wedekind | News

2 April 2026

6 comments 6 comments

Deborah James smiling at the camera while sitting on a sofa in a floral dress
Credit: Holly Clark

The Bowelbabe Fund for Cancer Research UK has surpassed a major milestone, raising more than £20 million to support lifesaving cancer research.

The fund was launched in May 2022 by Dame Deborah James, who set out with an initial target of £250,000 to back cutting-edge research projects she was passionate about while also driving awareness and challenging the stigma surrounding bowel cancer. Public support soared immediately, with donations taking the fund to £1 million in the first 24 hours.

Nearly four years later, the total has reached an extraordinary £20.5 million, marking a significant moment for the Fund and its ongoing impact.

Alongside announcing the fundraising milestone, the Bowelbabe Fund for Cancer Research UK confirmed it will support two new ambitious research projects, adding to the 14 initiatives it has already helped to fund. 

Remembering Dame Deborah James 

Deborah James, known as ‘Bowelbabe’, was diagnosed with bowel cancer in 2016 at the age of 35.

She was a tireless campaigner and fundraiser, sharing her cancer experience with unflinching honesty and tackling many taboos – including encouraging everyone to “check their poo”!   

In her final weeks, fuelled by her spirit of ‘rebellious hope’ and passion to help others, Deborah worked to establish the Bowelbabe Fund for Cancer Research UK. The Fund would support projects she was passionate about to help give more people affected by cancer more time with the people they love. This included working with others such as The Institute of Cancer Research, London, The Royal Marsden and Bowel Cancer UK.

When Deborah died on 28 June 2022, the Fund had raised nearly £7m.

The Bowelbabe Vaccine and advancing early detection

Deborah’s family are continuing her remarkable legacy by selecting the next round of research projects that will help support even more people affected by cancer.

One of the newly backed initiatives is the Bowelbabe Vaccine project developed by researchers from Cardiff University. The team are aiming to develop a bowel cancer vaccine that could be used to treat as many people with the disease as possible. The approach uses specific proteins found on bowel cancer cells, known as antigens, to train the immune system to recognise and attack them.

At the moment, bowel cancer vaccines in clinical trials are individually tailored for each person, which is time‑consuming and expensive. The team behind the Bowelbabe Vaccine hopes to change that by creating a more accessible option. If successful, researchers believe they could use the same approach to prevent bowel cancer in people at high risk and pave the way for a new generation of vaccines targeting other cancer types, potentially saving many more lives.

“Deborah would be absolutely over the moon if she were here today to see this. I don’t think any of us ever imagined reaching the £20m milestone when she first set up the Bowelbabe Fund for Cancer Research UK almost four years ago,” said Heather James, Deborah’s mother.

“She was so passionate about supporting research that would help give more people affected by cancer more time with their loved ones. Thanks to the wonderful generosity of everyone who has donated, walked, ran or even danced for Deborah, we’ve been able to come together once again as a family to choose another round of projects to support. I can almost feel her excitement in the room each time we do.”

The second project focuses on improving early detection of bowel cancer. Researchers at Queen’s University Belfast and the University of Glasgow are working to develop more accurate tests that can predict a person’s risk of developing new bowel growths, known as polyps, after existing polyps have been removed during a colonoscopy. These polyps can sometimes progress into cancer if not caught early.

The team aims to identify more reliable biological patterns, or biomarkers, that could be detected using tools already available within the NHS to help prevent more bowel cancers or detect them earlier.

Taking on the challenge 

The Bowelbabe Fund also announced in March that it will support the Cancer Grand Challenges team REWIRE‑CAN. This international group of scientists is taking on the urgent problem of advanced bowel cancers that no longer respond to standard treatments.

REWIRE‑CAN is taking an unconventional approach. The team aims to push cancer cells into overdrive so they burn out and self-destruct. They will also be looking for ways to reprogramme treatment‑resistant tumours so they respond to therapy again. Their work could open up entirely new strategies for tackling one of the most difficult aspects of bowel cancer.

“Thanks to research, more than half of people diagnosed with bowel cancer in the UK will survive the disease,” said Michelle Mitchell, chief executive of Cancer Research UK. “But there is still much more to do. These new projects are another example of the hope and progress being fuelled by research in Dame Deborah’s name.”

To help the Bowelbabe Fund continue its mission, donate directly at Bowelbabefund.org.

    Comments

  • judith Coley
    20 April 2026

    This is wonderful news and Deborah would be delighted. My mother died in her 80s of bowel cancer, 30 yrs ago. I have ibs but I know there is a possibility for me and my family.
    Many thanks to the Bowelbabe fund.

  • Craig Johnson
    18 April 2026

    This is amazing to hear. To be honest I do do a fair bit of reading on on going Bowel research along with research into the KRAS mutation- and why is so hard to treat out of all the trigger mutations associated with the disease. I was diagnosed in 2024 with stage 4 incurable BC after my initial diagnosis and was shocked more by the follow up CT scan results showing just as big a tumour in my liver (non operable) as my surgeon had removed from my Sigmoid).

    So, currently I’m tolerating well Bevacizumab with Lonsurf and have actually shown better results with this combination than the previous two lines of CAPOX and Folfiri. I was more curious as to why this KRAS G12V mutation is so prolific and equally so inert to lines of treatment. But if and when come to the end of palliative lines of treatment if they’d offer a trial I’d certainly take it. I’m not trying to outlive my time here either- I’ve accepted my prognosis isn’t great, so I’m concentrating on keeping myself as healthy as I can for as long as I can- but not all of us stage 4 bowel C patients fall in line with the 16-24months median either! I’d be very interested in following this Bowel Vaccine research programme even if it’s too late for myself. Good luck and please keep us in the loop!

  • Margaret Douglas
    18 April 2026

    Not suffering from Bowel Cancer but affected by other bowel issues, I fully understand the need to SHOUT out about it. It is very difficult to talk about these issues to Consultants, Nurses etc. (even being a retired Nurse) without feeling embarassed but is great to see Posters, Banners in local Cancer shops talking about it and on Toilet Roll packs, in Public toilets etc.
    It’s always a shame that it takes Dame Deborah’s Parents, Family and her wider friends to loose someone to get an important message across about an everyday function of Bowels.
    Good luck to the Research Teams and a big THANK YOU to Dame Deborah’s Legacy, for the help she has made to masses of other people who are now here to talk about it.

  • Jenny Forkes
    17 April 2026

    This is wonderful news! As my mother, and this year my sister, both had bowel cancer, I am very aware of this particular cancer. The postal screening kits are being returned regularly by my daughter and me. I am donating today, and send grateful thanks to all the Team.

  • J A (Tony) Booth
    15 April 2026

    In August 2024, I was diagnosed with bowel cancer, a 5cm tumour at the beginning of my large intestine. Because Christies (on behalf os GSK) were conducting a clinical trial of an immunotherapy treatment for the type of tumour I had, I was offered a place on the trial, and took it. I was initially disappointed when the randomising process put me in the “control” group, and I had keyhole surgery to remove the tumour, but pleased to find out that the cancer had not even spread to the lymph nodes (I was stage 2). I made a full recovery back to full fitness within a few days (that was a surprise) and will be monitored by Christies for another 4 years, to the end of the trial period. I don’t know if the immunotherapy you are supporting is the same one, but I thought you may be interested in my experience of the treatment, and I am certainly happy to have taken part in a trial to advance medical knowledge.

  • Glen Johnson
    15 April 2026

    This is fantastic news. If it was not for her great work on awareness, I would have ignored my symptoms back in 2024. Thankfully we caught it at stage 1 and after surgery, I have been cancer free for close to two years now. It’s great to read stories like this to see the amazing research going on to help support others who may be affected by this disease in the future.

Tell us what you think

Leave a Reply

Your email address will not be published. Required fields are marked *

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    Comments

  • judith Coley
    20 April 2026

    This is wonderful news and Deborah would be delighted. My mother died in her 80s of bowel cancer, 30 yrs ago. I have ibs but I know there is a possibility for me and my family.
    Many thanks to the Bowelbabe fund.

  • Craig Johnson
    18 April 2026

    This is amazing to hear. To be honest I do do a fair bit of reading on on going Bowel research along with research into the KRAS mutation- and why is so hard to treat out of all the trigger mutations associated with the disease. I was diagnosed in 2024 with stage 4 incurable BC after my initial diagnosis and was shocked more by the follow up CT scan results showing just as big a tumour in my liver (non operable) as my surgeon had removed from my Sigmoid).

    So, currently I’m tolerating well Bevacizumab with Lonsurf and have actually shown better results with this combination than the previous two lines of CAPOX and Folfiri. I was more curious as to why this KRAS G12V mutation is so prolific and equally so inert to lines of treatment. But if and when come to the end of palliative lines of treatment if they’d offer a trial I’d certainly take it. I’m not trying to outlive my time here either- I’ve accepted my prognosis isn’t great, so I’m concentrating on keeping myself as healthy as I can for as long as I can- but not all of us stage 4 bowel C patients fall in line with the 16-24months median either! I’d be very interested in following this Bowel Vaccine research programme even if it’s too late for myself. Good luck and please keep us in the loop!

  • Margaret Douglas
    18 April 2026

    Not suffering from Bowel Cancer but affected by other bowel issues, I fully understand the need to SHOUT out about it. It is very difficult to talk about these issues to Consultants, Nurses etc. (even being a retired Nurse) without feeling embarassed but is great to see Posters, Banners in local Cancer shops talking about it and on Toilet Roll packs, in Public toilets etc.
    It’s always a shame that it takes Dame Deborah’s Parents, Family and her wider friends to loose someone to get an important message across about an everyday function of Bowels.
    Good luck to the Research Teams and a big THANK YOU to Dame Deborah’s Legacy, for the help she has made to masses of other people who are now here to talk about it.

  • Jenny Forkes
    17 April 2026

    This is wonderful news! As my mother, and this year my sister, both had bowel cancer, I am very aware of this particular cancer. The postal screening kits are being returned regularly by my daughter and me. I am donating today, and send grateful thanks to all the Team.

  • J A (Tony) Booth
    15 April 2026

    In August 2024, I was diagnosed with bowel cancer, a 5cm tumour at the beginning of my large intestine. Because Christies (on behalf os GSK) were conducting a clinical trial of an immunotherapy treatment for the type of tumour I had, I was offered a place on the trial, and took it. I was initially disappointed when the randomising process put me in the “control” group, and I had keyhole surgery to remove the tumour, but pleased to find out that the cancer had not even spread to the lymph nodes (I was stage 2). I made a full recovery back to full fitness within a few days (that was a surprise) and will be monitored by Christies for another 4 years, to the end of the trial period. I don’t know if the immunotherapy you are supporting is the same one, but I thought you may be interested in my experience of the treatment, and I am certainly happy to have taken part in a trial to advance medical knowledge.

  • Glen Johnson
    15 April 2026

    This is fantastic news. If it was not for her great work on awareness, I would have ignored my symptoms back in 2024. Thankfully we caught it at stage 1 and after surgery, I have been cancer free for close to two years now. It’s great to read stories like this to see the amazing research going on to help support others who may be affected by this disease in the future.

Tell us what you think

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Read our comment policy.