Cancer Grand Challenges

• Science & Technology

Studying precancer to prevent cancer: ecDNA in Barrett's oesophagus

Cancer Grand Challenges team eDyNAmiC has changed our understanding of how oesophageal cancer starts. In some cases, mutations scientists thought were a late effect of the disease could actually be driving it in the first place. The findings could give us a new way to intercept cancer before it becomes dangerous. Cancer Grand Challenges team eDyNAmiC has changed our understanding of how oesophageal cancer starts. In some cases, mutations scientists thought were a late effect of the disease could actually be driving it in the first place. The findings could give us a new way to intercept cancer before it becomes dangerous.

23 October 2023

• Science & Technology
• Charity News

New scientific partnership between UK and France to tackle greatest challenges in cancer

Cancer Research UK and France’s Institut National Du Cancer (INCa) have announced a new scientific partnership to help fund world-class researchers to take on cancer’s toughest challenges Cancer Research UK and France’s Institut National Du Cancer (INCa) have announced a new scientific partnership to help fund world-class researchers to take on cancer’s toughest challenges

27 September 2023

• Charity News

International collaboration championed as Queen of Spain visits Cancer Research UK

Her Majesty Queen Letizia of Spain, honorary president of the Spanish Association Against Cancer (AECC), visited Cancer Research UK today to commemorate the upcoming World Cancer Research Day. Her Majesty Queen Letizia of Spain, honorary president of the Spanish Association Against Cancer (AECC), visited Cancer Research UK today to commemorate the upcoming World Cancer Research Day.

21 September 2023

• Science & Technology

The finalists seeking £20m to take on cancer's toughest challenges

The Cancer Grand Challenges shortlist includes 12 teams with the potential to make the progress against cancer that we urgently need. The Cancer Grand Challenges shortlist includes 12 teams with the potential to make the progress against cancer that we urgently need.

5 September 2023

• Science & Technology

The story of Cancer Grand Challenges so far

We're nearly 10 years into the Cancer Grand Challenges story. Dr Iain Foulkes, our executive director of Research & Innovation, gives an inside view on it. We're nearly 10 years into the Cancer Grand Challenges story. Dr Iain Foulkes, our executive director of Research & Innovation, gives an inside view on it.

4 September 2023

• Science & Technology

How clues from crystals might help us prevent the overtreatment of DCIS

New research may have found a way we can predict which cases of DCIS could develop into invasive breast cancer and thus require treatment, reducing the burden of overtreatment in future New research may have found a way we can predict which cases of DCIS could develop into invasive breast cancer and thus require treatment, reducing the burden of overtreatment in future

20 June 2023

• Science & Technology

Wasting syndrome: What is cachexia?

Cachexia is a complex syndrome which has puzzled researchers for decades. But with new research from Cancer Grand Challenges, we could be close to uncovering its mysteries. Cachexia is a complex syndrome which has puzzled researchers for decades. But with new research from Cancer Grand Challenges, we could be close to uncovering its mysteries.

19 June 2023

• Health & Medicine

Age: the forgotten cancer risk factor?

Ageing is often the ‘forgotten’ cancer risk factor, overshadowed by preventable risk factors like smoking and obesity. Now, Cancer Grand Challenges are bringing bringing the ‘forgotten’ cancer risk factor into the spotlight.  Ageing is often the ‘forgotten’ cancer risk factor, overshadowed by preventable risk factors like smoking and obesity. Now, Cancer Grand Challenges are bringing bringing the ‘forgotten’ cancer risk factor into the spotlight. 

29 May 2023

• Science & Technology
• Health & Medicine

Stopping neuropathy – one of chemotherapy’s most challenging side effects

Chemotherapy-induced peripheral neuropathy (CIPN) is caused by cancer treatment, but there's no way to treat it. Our work is changing that. Chemotherapy-induced peripheral neuropathy (CIPN) is caused by cancer treatment, but there's no way to treat it. Our work is changing that.

22 May 2023

• For Researchers

A career forged in team science

We spoke to Mariam Jamal-Hanjani and asked her to reflect on a career embedded in large-scale, collaborative and ambitious projects…    We spoke to Mariam Jamal-Hanjani and asked her to reflect on a career embedded in large-scale, collaborative and ambitious projects…   

10 March 2023

• Science & Technology
• Health & Medicine

Time to take on 9 new Cancer Grand Challenges

These are some of the biggest questions in cancer research. Cancer Grand Challenges are looking for research teams that can help answer them. These are some of the biggest questions in cancer research. Cancer Grand Challenges are looking for research teams that can help answer them.

8 March 2023

• Science & Technology

The ecDNA story – catching the mastermind behind cancer evolution

Aggressive cancers use ecDNA to evolve quickly and resist treatment. This is how we found that out, and how we're going to stop it. Aggressive cancers use ecDNA to evolve quickly and resist treatment. This is how we found that out, and how we're going to stop it.

20 February 2023