Brain (and spinal cord) tumours

Aggressive cancers use ecDNA to evolve quickly and resist treatment. This is how we found that out, and how we’re going to stop it.

Researchers at the University of Sheffield have developed a new magnetic device we could use to make more chemotherapy drugs effective against brain tumours.

We’ve helped double brain tumour survival over the past 40 years. Now, researchers are combining some of our most successful drugs, temozolomide and PARP inhibitors, to make glioblastoma treatment more effective.

Our scientists have found tiny cellular changes that make medulloblastomas resistant to treatment. Understanding them could help us treat the disease in future.

We spoke to Dr Debbie Hicks about what is being done to understand and minimise the impact of long-term side effects for children and young people with medulloblastoma.

“Our motivation for studying it is because there haven’t been any new effective treatments for decades.” Overall, survival for children’s…

The role of the nervous system in cancer progression remains largely unexplored. Now, our researchers at the Francis Crick Institute and Cancer Research UK Edinburgh Centre are leaning into the unknown to find out how cancer uses nerve cells and networks to survive and grow.

From groundbreaking rare cancer research to ending up on Forbes 30 under 30, we chat to Sigourney Bell about her work in the lab and her global organisation, Black in Cancer.

Since the 1970s, 30,000 deaths have been avoided thanks in part to the progress we’ve made in diagnosing and treating children’s and young people’s cancers.

This Childhood Cancer Awareness Month, we caught up with families who have been affected by children’s and young people’s cancers to find out how COVID-19 has impacted them and their loved ones.