Cancer Research Matters – A PARPing success

Cancer Research Matters will provoke conversation around cancer science, how it shapes our understanding of the disease and the challenges we face as we develop therapies.

The first series focusses on the 20^th anniversary of CRUK – we’ll be winding back the clock on some of the great discoveries and breakthroughs made in the past two decades and asking some leading names where they think we’ll be in another 20 years.

The first episode features Ruth Plummer. Ruth is Professor of Experimental Cancer Medicine at Newcastle University and Director of the CRUK Newcastle Cancer Centre. She talks about how the DNA repair inhibition field has changed over 20 years, her instrumental role in the development of the PARP inhibitor Rucaparib and why work/life balance is so important for the future of research life.

If you’d rather listen via the podcast site – click here

Further reading on PARP inhibitors

The development and translation of PARP inhibitors:

https://news.cancerresearchuk.org/2020/09/24/parp-inhibitors-halting-cancer-by-halting-dna-repair/

Paper showing the link between PARP and BRCA:

https://www.nature.com/articles/nature03445

General information on PARP inhibitors:

https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/targeted-cancer-drugs/types/PARP-inhibitors