Cancer biology

• For Researchers

Thinking outside the chromosome – how ecDNA is challenging conventional thinking

What is extrachromosomal DNA? How have we come to think of its role in cancer? And what has all this got to do with a flagship lung cancer study? What is extrachromosomal DNA? How have we come to think of its role in cancer? And what has all this got to do with a flagship lung cancer study?

11 November 2022

• Science & Technology

Stopping the spread: A revolution in how we think about metastasis

Research from our Cambridge Institute has shown us that metastasis isn’t a process unique to cancer, revolutionising the way we think about cell dissemination.  Research from our Cambridge Institute has shown us that metastasis isn’t a process unique to cancer, revolutionising the way we think about cell dissemination. 

18 October 2022

• Health & Medicine

NICE doesn’t recommend olaparib for patients with certain prostate cancers

NICE does not recommend olaparib (Lynparza) for people with a type of advanced prostate cancer, as the treatment is not deemed cost-effective NICE does not recommend olaparib (Lynparza) for people with a type of advanced prostate cancer, as the treatment is not deemed cost-effective

13 September 2022

• Science & Technology

Picking out the patterns: How scientists are finding cancer’s signatures in tumour DNA

An international team of researchers have identified 21 common faults in cancer DNA using an algorithm that works similarly to Netflix An international team of researchers have identified 21 common faults in cancer DNA using an algorithm that works similarly to Netflix

15 June 2022

• Science & Technology
• For Researchers

Disease in a dish: Mini-gut organoids and the challenges of bowel cancer

Disrupted cell signalling, hijacked stem cells and the power of 'mini-guts' – we hear from Dr Vivian Li on the challenges and opportunities of developing colorectal cancer treatments. Disrupted cell signalling, hijacked stem cells and the power of 'mini-guts' – we hear from Dr Vivian Li on the challenges and opportunities of developing colorectal cancer treatments.

11 February 2022

• For Researchers

Taking on DNA repair to tackle cancer

Pioneering therapeutics targeting the damage repair mechanism of DNA polymerase theta in a range of cancers have entered human trials - we tell the story from discovery to translation. Pioneering therapeutics targeting the damage repair mechanism of DNA polymerase theta in a range of cancers have entered human trials - we tell the story from discovery to translation.

5 November 2021

• Science & Technology

Unravelling the mystery of Barrett’s oesophagus

Barrett’s oesophagus affects around 1 in every 100 to 200 people in the UK, and, for a small number of people, can develop into oesophageal cancer. But the origins of the condition have remained a mystery for decades, until now. Barrett’s oesophagus affects around 1 in every 100 to 200 people in the UK, and, for a small number of people, can develop into oesophageal cancer. But the origins of the condition have remained a mystery for decades, until now.

25 October 2021

• For Researchers
• Science & Technology

How cancer hijacks cell death: a new view of metastasis

Professor Jody Rosenblatt tells us why dysregulated cell death could have an impact not only on metastasis, but also therapy resistance. Professor Jody Rosenblatt tells us why dysregulated cell death could have an impact not only on metastasis, but also therapy resistance.

17 September 2021

• Science & Technology

Scientists find cells in centre of tumours are most likely to spread

The new findings shed light on how cancer cells found in different parts of a tumour behave differently. The new findings shed light on how cancer cells found in different parts of a tumour behave differently.

19 May 2021

• Science & Technology

Stressed out – the cancer cells that survive chemotherapy, but at a cost

A group of Cancer Research UK-funded scientists are beginning to discover new vulnerabilities in cancer cells, which emerge when they enter ‘survival mode’. A group of Cancer Research UK-funded scientists are beginning to discover new vulnerabilities in cancer cells, which emerge when they enter ‘survival mode’.

29 April 2021

• Science & Technology

New method analyses DNA changes with ‘unprecedented accuracy’

Using the technology, scientists have revealed that cell division isn’t necessarily the main cause of genetic changes in human tissue DNA. Using the technology, scientists have revealed that cell division isn’t necessarily the main cause of genetic changes in human tissue DNA.

29 April 2021