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Taking on DNA repair to tackle cancer

Pioneering therapeutics targeting the damage repair mechanism of DNA polymerase theta in a range of cancers have entered human trials – we tell the story from discovery to translation.

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The award-winning researcher behind next generation sequencing

We speak to Professor Shankar Balasubramanian about his work on NGS, his incredible translational journey and the power of the pub…

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New method analyses DNA changes with ‘unprecedented accuracy’

Using the technology, scientists have revealed that cell division isn’t necessarily the main cause of genetic changes in human tissue DNA.

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Genetic changes in tumours may predict who will respond to immunotherapy

Genetic changes in tumours could be used to predict who will benefit from immunotherapy, and who should receive other treatments. 

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Discovering the BRCA2 gene – 25 years on

25 years ago, a team of our scientists were celebrating. Their risky strategy had paid off.

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Evolution, sex and TRACERx: how cancer’s ‘spare tyre’ helps it survive  

New research reveals how some cancer cells double their genome to help them survive. Find out more about cancer’s ‘spare tyre’.

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So-called ‘junk DNA’ affects inherited cancer risk

Research reveals how genetic variations in the regions of DNA that don’t code for proteins, once dismissed as ‘junk DNA’, can affect a person’s risk of cancer.

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Gene editing uncovers potential drug targets for aggressive brain tumours

Potential new drug targets for an aggressive type of brain tumour have been uncovered in the lab, thanks to a ‘reverse engineering’ approach using DNA editing.

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Why do certain faulty genes only cause cancer in some parts of the body?

Our international team of scientists are tackling a fundamental question about how cancer develops: why do some gene faults only cause cancer in certain organs?

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Scientists use DNA-editing tool CRISPR to catalogue cancer’s weaknesses

UK scientists are putting together a list of the most promising potential cancer drug targets in one of the largest lab studies of its kind.

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