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New method analyses DNA changes with ‘unprecedented accuracy’

Using the technology, scientists have revealed that cell division isn’t necessarily the main cause of genetic changes in human tissue DNA.

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Genetic changes in tumours may predict who will respond to immunotherapy

Genetic changes in tumours could be used to predict who will benefit from immunotherapy, and who should receive other treatments. 

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Discovering the BRCA2 gene – 25 years on

25 years ago, a team of our scientists were celebrating. Their risky strategy had paid off.

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Evolution, sex and TRACERx: how cancer’s ‘spare tyre’ helps it survive  

New research reveals how some cancer cells double their genome to help them survive. Find out more about cancer’s ‘spare tyre’.

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So-called ‘junk DNA’ affects inherited cancer risk

Research reveals how genetic variations in the regions of DNA that don’t code for proteins, once dismissed as ‘junk DNA’, can affect a person’s risk of cancer.

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Gene editing uncovers potential drug targets for aggressive brain tumours

Potential new drug targets for an aggressive type of brain tumour have been uncovered in the lab, thanks to a ‘reverse engineering’ approach using DNA editing.

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Why do certain faulty genes only cause cancer in some parts of the body?

This entry is part 21 of 26 in the series Cancer Grand Challenges

Our international team of scientists are tackling a fundamental question about how cancer develops: why do some gene faults only cause cancer in certain organs?

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Scientists use DNA-editing tool CRISPR to catalogue cancer’s weaknesses

UK scientists are putting together a list of the most promising potential cancer drug targets in one of the largest lab studies of its kind.

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The immune system preys on growing lung cancers, forcing them to evolve to survive

Scientists are taking a leaf out of Darwin’s evolutionary handbook to understand how lung cancer evolves.

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Rewriting the breast cancer rulebook 

Our scientists have found that breast cancer is not 1 but 10 different diseases, each with a different risk of coming back or spreading.

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